Skip to content

Sickle Cell Disease

Crisis Prevention

Pharmacological Induction of Fetal Hemoglobin

Systematic review: hydroxyurea for the treatment of adults with sickle cell disease. (opens new window)

Lanzkron S, Strouse JJ, Wilson R, Beach MC, Haywood C, Park H, Witkop C, Bass EB, Segal JB.

Source‎: Ann Intern Med 2008;148(12):939-55.

Indexed‎: PubMed 18458272 (opens new window)

Hydroxyurea for the treatment of sickle cell anemia. (opens new window)

Platt OS.

Source‎: N Engl J Med 2008;358(13):1362-9.

Indexed‎: PubMed 18367739

DOI‎: 10.1056/NEJMct0708272 (opens new window)

Clinical effectiveness of decitabine in severe sickle cell disease. (opens new window)

Saunthararajah Y, Molokie R, Saraf S, Sidhwani S, Gowhari M, Vara S, Lavelle D, DeSimone J.

Source‎: Br J Haematol 2008;141(1):126-9.

Indexed‎: PubMed 18324975

DOI‎: 10.1111/j.1365-2141.2008.07027.x (opens new window)

The effect of prolonged administration of hydroxyurea on morbidity and mortality in adult patients with sickle cell syndromes: results of a 17-year, single-center trial (LaSHS). (opens new window)

Voskaridou E, Christoulas D, Bilalis A, Plata E, Varvagiannis K, Stamatopoulos G, Sinopoulou K, Balassopoulou A, Loukopoulos D, Terpos E.

Source‎: Blood 2010;115(12):2354-63.

Indexed‎: PubMed 19903897

DOI‎: 10.1182/blood-2009-05-221333 (opens new window)

Prevention of Infections and Other Complications

Prophylactic antibiotics for preventing pneumococcal infection in children with sickle cell disease. (opens new window)

Hirst C, Owusu-Ofori S.

Source‎: Cochrane Database Syst Rev 2012;(9):CD003427.

Indexed‎: PubMed 22972063

DOI‎: 10.1002/14651858.CD003427.pub2 (opens new window)

Voxelotor in adolescents and adults with sickle cell disease (HOPE): long-term follow-up results of an international, randomised, double-blind, placebo-controlled, phase 3 trial. (opens new window)

Howard J, Ataga KI, Brown RC, Achebe M, Nduba V, El-Beshlawy A, Hassab H, Agodoa I, Tonda M, Gray S, Lehrer-Graiwer J, Vichinsky E

Source‎: Lancet Haematol 2021;8(5):e323-33.

Indexed‎: PubMed 33838113

DOI‎: 10.1016/S2352-3026(21)00059-4 (opens new window)

Sickle cell disease. (opens new window)

Meremikwu MM, Okomo U.

Source‎: BMJ Clin Evid 2011;02:2402.

Indexed‎: PubMed 21718552 (opens new window)

A phase 3 trial of l-glutamine in sickle cell disease. (opens new window)

Niihara Y, Miller ST, Kanter J, Lanzkron S, Smith WR, Hsu LL, Gordeuk VR, Viswanathan K, Sarnaik S, Osunkwo I, Guillaume E, Sadanandan S, Sieger L, Lasky JL, Panosyan EH, Blake OA, New TN, Bellevue R, Tran LT, Razon RL, Stark CW, Neumayr LD, Vichinsky EP

Source‎: N Engl J Med 2018;379(3):226-35.

Indexed‎: PubMed 30021096

DOI‎: 10.1056/NEJMoa1715971 (opens new window)

Malaria chemoprophylaxis in sickle cell disease. (opens new window)

Oniyangi O, Omari AA.

Source‎: Cochrane Database Syst Rev 2006;(4):CD003489.

Indexed‎: PubMed 17054173

DOI‎: 10.1002/14651858.CD003489.pub2 (opens new window)