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Sickle Cell Disease

Management of Vaso-Occlusive Crisis and Acute Chest Syndrome

Pain Management

What is the best pharmacologic treatment for sickle cell disease pain crises? (opens new window)

Baker M, Hafner JW.

Source‎: Ann Emerg Med 2012;59(6):515-6.

Indexed‎: PubMed 22221839

DOI‎: 10.1016/j.annemergmed.2011.11.026 (opens new window)

Update on pain management in sickle cell disease. (opens new window)

Ballas SK.

Source‎: Hemoglobin 2011;35(5-6):520-9.

Indexed‎: PubMed 21910604

DOI‎: 10.3109/03630269.2011.610478 (opens new window)

Reduction of painful vaso-occlusive crisis of sickle cell anaemia by tinzaparin in a double-blind randomized trial. (opens new window)

Qari MH, Aljaouni SK, Alardawi MS, Fatani H, Alsayes FM, Zografos P, Alsaigh M, Alalfi A, Alamin M, Gadi A, Mousa SA.

Source‎: Thromb Haemost 2007;98(2):392-6.

Indexed‎: PubMed 17721622 (opens new window)

Hydration Therapy (Fluid Management)

Fluid replacement therapy for acute episodes of pain in people with sickle cell disease. (opens new window)

Okomo U, Meremikwu MM.

Source‎: Cochrane Database Syst Rev 2012;(6):CD005406.

Indexed‎: PubMed 22696351

DOI‎: 10.1002/14651858.CD005406.pub3 (opens new window)

Oxygen Supplementation

Guidelines for the management of the acute painful crisis in sickle cell disease. (opens new window)

Rees DC, Olujohungbe AD, Parker NE, Stephens AD, Telfer P, Wright J; British Committee for Standards in Haematology General Haematology Task Force by the Sickle Cell Working Party.

Source‎: Br J Haematol 2003;120(5):744-52.

Indexed‎: PubMed 12614204 (opens new window)

Hyperbaric oxygen therapy for vaso-occlusive crises in nine patients with sickle-cell disease. (opens new window)

Stirnemann J, Letellier E, Aras N, Borne M, Brinquin L, Fain O.

Source‎: Diving Hyperb Med 2012;42(2):82-4.

Indexed‎: PubMed 22828815 (opens new window)

Antibiotic and Respiratory Therapy

Safety of purified poloxamer 188 in sickle cell disease: phase I study of a non-ionic surfactant in the management of acute chest syndrome. (opens new window)

Ballas SK, Files B, Luchtman-Jones L, Benjamin L, Swerdlow P, Hilliard L, Coates T, Abboud M, Wojtowicz-Praga S, Grindel JM.

Source‎: Hemoglobin 2004;28(2):85-102.

Indexed‎: PubMed 15182051 (opens new window)

Incentive spirometry to prevent acute pulmonary complications in sickle cell diseases. (opens new window)

Bellet PS, Kalinyak KA, Shukla R, Gelfand MJ, Rucknagel DL.

Source‎: N Engl J Med 1995;333(11):699-703.

Indexed‎: PubMed 7637747

DOI‎: 10.1056/NEJM199509143331104 (opens new window)

Continuous inhaled nitric oxide therapy in a case of sickle cell disease with multiorgan involvement. (opens new window)

Chang WL, Corate LM, Sinclair JM, van der Heyde HC.

Source‎: J Investig Med 2008;56(8):1023-7.

Indexed‎: PubMed 19050460

DOI‎: 10.2310/JIM.0b013e31818cb612 (opens new window)

Causes and outcomes of the acute chest syndrome in sickle cell disease. National Acute Chest Syndrome Study Group. (opens new window)

Vichinsky EP, Neumayr LD, Earles AN, Williams R, Lennette ET, Dean D, Nickerson B, Orringer E, McKie V, Bellevue R, Daeschner C, Manci EA.

Source‎: N Engl J Med 2000;342(25):1855-65.

Indexed‎: PubMed 10861320

DOI‎: 10.1056/NEJM200006223422502 (opens new window)