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Sickle Cell Disease (Pediatrics)

Management of Vaso-Occlusive Crisis and Acute Chest Syndrome

Pain Management

What is the best pharmacologic treatment for sickle cell disease pain crises? (opens new window)

Baker M, Hafner JW.

Source‎: Ann Emerg Med 2012;59(6):515-6.

Indexed‎: PubMed 22221839

DOI‎: 10.1016/j.annemergmed.2011.11.026 (opens new window)

Reduction of painful vaso-occlusive crisis of sickle cell anaemia by tinzaparin in a double-blind randomized trial. (opens new window)

Qari MH, Aljaouni SK, Alardawi MS, Fatani H, Alsayes FM, Zografos P, Alsaigh M, Alalfi A, Alamin M, Gadi A, Mousa SA.

Source‎: Thromb Haemost 2007;98(2):392-6.

Indexed‎: PubMed 17721622 (opens new window)

Hydration Therapy (Fluid Management)

Fluid replacement therapy for acute episodes of pain in people with sickle cell disease. (opens new window)

Okomo U, Meremikwu MM.

Source‎: Cochrane Database Syst Rev 2012;(6):CD005406.

Indexed‎: PubMed 22696351

DOI‎: 10.1002/14651858.CD005406.pub3 (opens new window)

Oxygen Supplementation

Guidelines for the management of the acute painful crisis in sickle cell disease. (opens new window)

Rees DC, Olujohungbe AD, Parker NE, Stephens AD, Telfer P, Wright J; British Committee for Standards in Haematology General Haematology Task Force by the Sickle Cell Working Party.

Source‎: Br J Haematol 2003;120(5):744-52.

Indexed‎: PubMed 12614204 (opens new window)

Antibiotic and Respiratory Therapy

The use of incentive spirometry in pediatric patients with sickle cell disease to reduce the incidence of acute chest syndrome. (opens new window)

Ahmad FA, Macias CG, Allen JY.

Source‎: J Pediatr Hematol Oncol 2011;33(6):415-20.

Indexed‎: PubMed 21792036

DOI‎: 10.1097/MPH.0b013e31821ed4ce (opens new window)

Safety of purified poloxamer 188 in sickle cell disease: phase I study of a non-ionic surfactant in the management of acute chest syndrome. (opens new window)

Ballas SK, Files B, Luchtman-Jones L, Benjamin L, Swerdlow P, Hilliard L, Coates T, Abboud M, Wojtowicz-Praga S, Grindel JM.

Source‎: Hemoglobin 2004;28(2):85-102.

Indexed‎: PubMed 15182051 (opens new window)

A short course of prednisone in the management of acute chest syndrome of sickle cell disease. (opens new window)

Kumar R, Qureshi S, Mohanty P, Rao SP, Miller ST.

Source‎: J Pediatr Hematol Oncol 2010;32(3):e91-4.

Indexed‎: PubMed 20216237

DOI‎: 10.1097/MPH.0b013e3181c29c52 (opens new window)

A randomized, placebo-controlled trial of arginine therapy for the treatment of children with sickle cell disease hospitalized with vaso-occlusive pain episodes. (opens new window)

Morris CR, Kuypers FA, Lavrisha L, Ansari M, Sweeters N, Stewart M, Gildengorin G, Neumayr L, Vichinsky EP.

Source‎: Haematologica 2013;98(9):1375-82.

Indexed‎: PubMed 23645695

DOI‎: 10.3324/haematol.2013.086637 (opens new window)

Predictors of bacteremia in febrile children with sickle cell disease. (opens new window)

West DC, Andrada E, Azari R, Rangaswami AA, Kuppermann N.

Source‎: J Pediatr Hematol Oncol 2002;24(4):279-83.

Indexed‎: PubMed 11972096 (opens new window)