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Perioperative Care (Pediatrics)

Management and Optimization of Hemostasis

Antifibrinolytic Agents

A systematic review of the use of antifibrinolytic agents in pediatric surgery and implications for craniofacial use. (opens new window)

Basta MN, Stricker PA, Taylor JA.

Source‎: Pediatr Surg Int 2012;28(11):1059-69.

Indexed‎: PubMed 22940882

DOI‎: 10.1007/s00383-012-3167-6

https://www.ncbi.nlm.nih.gov/pubmed/22940882 (opens new window)

Use of tranexamic acid as a rescue measure to achieve hemostasis after massive blood loss in a pediatric neurosurgical patient. (opens new window)

Bharath K, Bhagat H, Mohindra S.

Source‎: J Neurosurg Anesthesiol 2011;23(4):376-7.

Indexed‎: PubMed 21876453

DOI‎: 10.1097/ANA.0b013e31822c804f

https://www.ncbi.nlm.nih.gov/pubmed/21876453 (opens new window)

Aprotinin, transfusions, and kidney injury in neonates and infants undergoing cardiac surgery. (opens new window)

Bojan M, Vicca S, Boulat C, Gioanni S, Pouard P.

Source‎: Br J Anaesth 2012;108(5):830-7.

Indexed‎: PubMed 22362670

DOI‎: 10.1093/bja/aes002

https://www.ncbi.nlm.nih.gov/pubmed/22362670 (opens new window)

Efficacy and safety of prophylactic large dose of tranexamic acid in spine surgery: a prospective, randomized, double-blind, placebo-controlled study. (opens new window)

Elwatidy S, Jamjoom Z, Elgamal E, Zakaria A, Turkistani A, El-Dawlatly A.

Source‎: Spine (Phila Pa 1976) 2008;33(24):2577-80.

Indexed‎: PubMed 19011538

DOI‎: 10.1097/BRS.0b013e318188b9c5

https://www.ncbi.nlm.nih.gov/pubmed/19011538 (opens new window)

A randomized control trial to verify the efficacy of pre-operative intravenous tranexamic acid in the control of tonsillectomy bleeding. (opens new window)

George A, Kumar R, Kumar S, Shetty S.

Source‎: Indian J Otolaryngol Head Neck Surg 2011;63(1):20-6.

Indexed‎: PubMed 22319712

DOI‎: 10.1007/s12070-010-0095-4

https://www.ncbi.nlm.nih.gov/pubmed/22319712 (opens new window)

Efficacy of tranexamic acid in pediatric craniosynostosis surgery: a double-blind, placebo-controlled trial. (opens new window)

Goobie SM, Meier PM, Pereira LM, McGowan FX, Prescilla RP, Scharp LA, Rogers GF, Proctor MR, Meara JG, Soriano SG, Zurakowski D, Sethna NF.

Source‎: Anesthesiology 2011;114(4):862-71.

Indexed‎: PubMed 21364458

DOI‎: 10.1097/ALN.0b013e318210fd8f

https://www.ncbi.nlm.nih.gov/pubmed/21364458 (opens new window)

Tranexamic acid is efficacious at decreasing the rate of blood loss in adolescent scoliosis surgery: a randomized placebo-controlled trial. (opens new window)

Goobie SM, Zurakowski D, Glotzbecker MP, McCann ME, Hedequist D, Brustowicz RM, Sethna NF, Karlin LI, Emans JB, Hresko MT

Source‎: J Bone Joint Surg Am 2018;100(23):2024-32.

Indexed‎: PubMed 30516625

DOI‎: 10.2106/JBJS.18.00314

https://www.ncbi.nlm.nih.gov/pubmed/30516625 (opens new window)

Differential effects of aprotinin and tranexamic acid on outcomes and cytokine profiles in neonates undergoing cardiac surgery. (opens new window)

Graham EM, Atz AM, Gillis J, Desantis SM, Haney AL, Deardorff RL, Uber WE, Reeves ST, McGowan FX Jr, Bradley SM, Spinale FG.

Source‎: J Thorac Cardiovasc Surg 2012;143(5):1069-76.

Indexed‎: PubMed 22075061

DOI‎: 10.1016/j.jtcvs.2011.08.051

https://www.ncbi.nlm.nih.gov/pubmed/22075061 (opens new window)

Anesthetic management for transfusion-free Rastelli's procedure in a pediatric Jehovah's Witness patient. (opens new window)

Kang SH, Song I, Kang JE, Lee JH, Kim JT.

Source‎: Korean J Anesthesiol 2013;65(6 Suppl):S87-8.

Indexed‎: PubMed 24478887

DOI‎: 10.4097/kjae.2013.65.6S.S87

https://www.ncbi.nlm.nih.gov/pubmed/24478887 (opens new window)

The safety and efficacy of antifibrinolytic therapy in neonatal cardiac surgery. (opens new window)

Lin CY, Shuhaiber JH, Loyola H, Liu H, Del Nido P, DiNardo JA, Pigula FA.

Source‎: PLoS One 2015;10(5):e0126514.

Indexed‎: PubMed 25954976

DOI‎: 10.1371/journal.pone.0126514

https://www.ncbi.nlm.nih.gov/pubmed/25954976 (opens new window)

Tranexamic acid versus ɛ-aminocaproic acid: efficacy and safety in paediatric cardiac surgery. (opens new window)

Martin K, Breuer T, Gertler R, Hapfelmeier A, Schreiber C, Lange R, Hess J, Wiesner G.

Source‎: Eur J Cardiothorac Surg 2011;39(6):892-7.

Indexed‎: PubMed 21115357

DOI‎: 10.1016/j.ejcts.2010.09.041

https://www.ncbi.nlm.nih.gov/pubmed/21115357 (opens new window)

Antifibrinolytic agents reduce blood loss during pediatric vertebral column resection procedures. (opens new window)

Newton PO, Bastrom TP, Emans JB, Shah SA, Shufflebarger HL, Sponseller PD, Sucato DJ, Lenke LG.

Source‎: Spine (Phila Pa 1976) 2012;37(23):E1459-63.

Indexed‎: PubMed 22872217

DOI‎: 10.1097/BRS.0b013e31826c9fe4

https://www.ncbi.nlm.nih.gov/pubmed/22872217 (opens new window)

Comparative analysis of antifibrinolytic medications in pediatric heart surgery. (opens new window)

Pasquali SK, Li JS, He X, Jacobs ML, O'Brien SM, Hall M, Jaquiss RD, Welke KF, Peterson ED, Shah SS, Jacobs JP.

Source‎: J Thorac Cardiovasc Surg 2012;143(3):550-7.

Indexed‎: PubMed 22264414

DOI‎: 10.1016/j.jtcvs.2011.06.048

https://www.ncbi.nlm.nih.gov/pubmed/22264414 (opens new window)

Use of tranexamic acid in infants undergoing choroid plexus papilloma surgery: a report of two cases. (opens new window)

Phi JH, Goobie SM, Hong KH, Dholakia A, Smith ER.

Source‎: Paediatr Anaesth 2014;24(7):791-3.

Indexed‎: PubMed 24924340

DOI‎: 10.1111/pan.12447

https://www.ncbi.nlm.nih.gov/pubmed/24924340 (opens new window)

The effect of aprotinin, tranexamic acid, and aminocaproic acid on blood loss and use of blood products in major pediatric surgery: a meta-analysis. (opens new window)

Schouten ES, van de Pol AC, Schouten AN, Turner NM, Jansen NJ, Bollen CW.

Source‎: Pediatr Crit Care Med 2009;10(2):182-90.

Indexed‎: PubMed 19188875

DOI‎: 10.1097/PCC.0b013e3181956d61

https://www.ncbi.nlm.nih.gov/pubmed/19188875 (opens new window)

The role of Amicar in same-day anterior and posterior spinal fusion for idiopathic scoliosis. (opens new window)

Thompson GH, Florentino-Pineda I, Poe-Kochert C, Armstrong DG, Son-Hing JP.

Source‎: Spine (Phila Pa 1976) 2008;33(20):2237-42.

Indexed‎: PubMed 18794767

DOI‎: 10.1097/BRS.0b013e31817bd889

https://www.ncbi.nlm.nih.gov/pubmed/18794767 (opens new window)

Comparison of three dose regimens of aprotinin in infants undergoing the arterial switch operation. (opens new window)

Verma YS, Chauhan S, Bisoi AK, Gharde P, Kiran U, Das SN.

Source‎: Ann Card Anaesth 2010;13(2):110-5.

Indexed‎: PubMed 20442540

DOI‎: 10.4103/0971-9784.62935

https://www.ncbi.nlm.nih.gov/pubmed/20442540 (opens new window)

Pharmacokinetics of tranexamic acid in neonates, infants, and children undergoing cardiac surgery with cardiopulmonary bypass. (opens new window)

Wesley MC, Pereira LM, Scharp LA, Emani SM, McGowan FX Jr, DiNardo JA.

Source‎: Anesthesiology 2015;122(4):746-58.

Indexed‎: PubMed 25585004

DOI‎: 10.1097/ALN.0000000000000570

https://www.ncbi.nlm.nih.gov/pubmed/25585004 (opens new window)

Does the intraoperative tranexamic acid decrease operative blood loss during posterior spinal fusion for treatment of adolescent idiopathic scoliosis? (opens new window)

Yagi M, Hasegawa J, Nagoshi N, Iizuka S, Kaneko S, Fukuda K, Takemitsu M, Shioda M, Machida M.

Source‎: Spine (Phila Pa 1976) 2012;37(21):E1336-42.

Indexed‎: PubMed 22772572

DOI‎: 10.1097/BRS.0b013e318266b6e5

https://www.ncbi.nlm.nih.gov/pubmed/22772572 (opens new window)

Recombinant Activated Factor VII (rFVIIa)

Pediatric off-label use of recombinant factor VIIa. (opens new window)

Alten JA, Benner K, Green K, Toole B, Tofil NM, Winkler MK.

Source‎: Pediatrics 2009;123(3):1066-72.

Indexed‎: PubMed 19255041

DOI‎: 10.1542/peds.2008-1685

https://www.ncbi.nlm.nih.gov/pubmed/19255041 (opens new window)

Recombinant activated factor VII usage in life threatening hemorrhage: a pediatric experience. (opens new window)

Bhat S, Yadav SP, Anjan M, Dinand V, Sachdeva A.

Source‎: Indian J Pediatr 2011;78(8):961-8.

Indexed‎: PubMed 21328080

DOI‎: 10.1007/s12098-011-0364-6

https://www.ncbi.nlm.nih.gov/pubmed/21328080 (opens new window)

Recombinant activated factor VII (rFVIIa) treatment in infants with hemorrhage. (opens new window)

Brady KM, Easley RB, Tobias JD.

Source‎: Paediatr Anaesth 2006;16(10):1042-6.

Indexed‎: PubMed 16972833

DOI‎: 10.1111/j.1460-9592.2006.02039.x

https://www.ncbi.nlm.nih.gov/pubmed/16972833 (opens new window)

Review of the off-label use of recombinant activated factor VII in pediatric cardiac surgery patients. (opens new window)

Guzzetta NA, Russell IA, Williams GD.

Source‎: Anesth Analg 2012;115(2):364-78.

Indexed‎: PubMed 22652310

DOI‎: 10.1213/ANE.0b013e31825aff10

https://www.ncbi.nlm.nih.gov/pubmed/22652310 (opens new window)

Use of recombinant activated factor VII for controlling refractory postoperative bleeding in children undergoing cardiac surgery with cardiopulmonary bypass. (opens new window)

Pychyńska-Pokorska M, Pągowska-Klimek I, Krajewski W, Moll JJ.

Source‎: J Cardiothorac Vasc Anesth 2011;25(6):987-94.

Indexed‎: PubMed 21835642

DOI‎: 10.1053/j.jvca.2011.05.012

https://www.ncbi.nlm.nih.gov/pubmed/21835642 (opens new window)

Recombinant activated factor VII for hemorrhage after pediatric cardiac surgery. (opens new window)

Singh SP, Chauhan S, Choudhary M, Vasdev S, Talwar S.

Source‎: Asian Cardiovasc Thorac Ann 2012;20(1):19-23.

Indexed‎: PubMed 22371937

DOI‎: 10.1177/0218492311432584

https://www.ncbi.nlm.nih.gov/pubmed/22371937 (opens new window)

Single-center experience: use of recombinant factor VIIa for acute life-threatening bleeding in children without congenital hemorrhagic disorder. (opens new window)

Yilmaz D, Karapinar B, Balkan C, Akisü M, Kavakli K.

Source‎: Pediatr Hematol Oncol 2008;25(4):301-11.

Indexed‎: PubMed 18484474

DOI‎: 10.1080/08880010802016904

https://www.ncbi.nlm.nih.gov/pubmed/18484474 (opens new window)

Off-label use of rFVIIa in children with excessive bleeding: a consecutive study of 153 off-label uses in 139 children. (opens new window)

Young G, Wicklund B, Neff P, Johnson C, Nugent DJ.

Source‎: Pediatr Blood Cancer 2009;53(2):179-83.

Indexed‎: PubMed 19415741

DOI‎: 10.1002/pbc.22053

https://www.ncbi.nlm.nih.gov/pubmed/19415741 (opens new window)

Coagulation Factor Concentrates

Emergent pediatric anticoagulation reversal using a 4-factor prothrombin complex concentrate. (opens new window)

Adams CB, Vollman KE, Leventhal EL, Acquisto NM.

Source‎: Am J Emerg Med 2016;34(6):1182.e1-2.

Indexed‎: PubMed 26652577

DOI‎: 10.1016/j.ajem.2015.10.041

https://www.ncbi.nlm.nih.gov/pubmed/26652577 (opens new window)

Perioperative monitoring of thromboelastograph on blood protection and recovery for severely cyanotic patients undergoing complex cardiac surgery. (opens new window)

Cui Y, Hei F, Long C, Feng Z, Zhao J, Yan F, Wang Y, Liu J.

Source‎: Artif Organs 2010;34(11):955-60.

Indexed‎: PubMed 21092037

DOI‎: 10.1111/j.1525-1594.2010.01148.x

https://www.ncbi.nlm.nih.gov/pubmed/21092037 (opens new window)

Plasma fibrinogen concentration is correlated with postoperative blood loss in children undergoing cardiac surgery. A retrospective review. (opens new window)

Faraoni D, Willems A, Savan V, Demanet H, De Ville A, Van der Linden P.

Source‎: Eur J Anaesthesiol 2014;31(6):317-26.

Indexed‎: PubMed 24503704

DOI‎: 10.1097/EJA.0000000000000043

https://www.ncbi.nlm.nih.gov/pubmed/24503704 (opens new window)

Hemostatic effects of fibrinogen concentrate compared with cryoprecipitate in children after cardiac surgery: a randomized pilot trial. (opens new window)

Galas FR, de Almeida JP, Fukushima JT, Vincent JL, Osawa EA, Zeferino S, Câmara L, Guimarães VA, Jatene MB, Hajjar LA.

Source‎: J Thorac Cardiovasc Surg 2014;148(4):1647-55.

Indexed‎: PubMed 24951020

DOI‎: 10.1016/j.jtcvs.2014.04.029

https://www.ncbi.nlm.nih.gov/pubmed/24951020 (opens new window)

Four-factor prothrombin complex concentrates in paediatric patients—a retrospective case series. (opens new window)

Noga T, Bruce AA, Blain H, Nahirniak S.

Source‎: Vox Sang 2016;110(3):253-7.

Indexed‎: PubMed 26509839

DOI‎: 10.1111/vox.12353

https://www.ncbi.nlm.nih.gov/pubmed/26509839 (opens new window)

Viscoelastic Tests to Identify Surgical or Coagulopathic Bleeding

Utility of Sonoclot analysis and tranexamic acid in tetralogy of Fallot patients undergoing intracardiac repair. (opens new window)

Aggarwal V, Kapoor PM, Choudhury M, Kiran U, Chowdhury U.

Source‎: Ann Card Anaesth 2012;15(1):26-31.

Indexed‎: PubMed 22234018

DOI‎: 10.4103/0971-9784.91477

https://www.ncbi.nlm.nih.gov/pubmed/22234018 (opens new window)

Perioperative bleeding management in pediatric patients. (opens new window)

Goobie SM, Haas T.

Source‎: Curr Opin Anaesthesiol 2016;29(3):352-8.

Indexed‎: PubMed 26844864

DOI‎: 10.1097/ACO.0000000000000308

https://www.ncbi.nlm.nih.gov/pubmed/26844864 (opens new window)

Management of dilutional coagulopathy during pediatric major surgery. (opens new window)

Haas T, Mauch J, Weiss M, Schmugge M.

Source‎: Transfus Med Hemother 2012;39(2):114-9.

Indexed‎: PubMed 22670129

DOI‎: 10.1159/000337245

https://www.ncbi.nlm.nih.gov/pubmed/22670129 (opens new window)

Higher fibrinogen concentrations for reduction of transfusion requirements during major paediatric surgery: a prospective randomised controlled trial. (opens new window)

Haas T, Spielmann N, Restin T, Seifert B, Henze G, Obwegeser J, Min K, Jeszenszky D, Weiss M, Schmugge M.

Source‎: Br J Anaesth 2015;115(2):234-43.

Indexed‎: PubMed 25982134

DOI‎: 10.1093/bja/aev136

https://www.ncbi.nlm.nih.gov/pubmed/25982134 (opens new window)

Thromboelastometry-guided intraoperative haemostatic management reduces bleeding and red cell transfusion after paediatric cardiac surgery. (opens new window)

Nakayama Y, Nakajima Y, Tanaka KA, Sessler DI, Maeda S, Iida J, Ogawa S, Mizobe T.

Source‎: Br J Anaesth 2015;114(1):91-102.

Indexed‎: PubMed 25303988

DOI‎: 10.1093/bja/aeu339

https://www.ncbi.nlm.nih.gov/pubmed/25303988 (opens new window)

Cardiac surgery without blood products in a Jehovah's Witness child with factor VII deficiency. (opens new window)

Pérez-Ferrer A, Gredilla E, de Vicente J, Laporta Y.

Source‎: J Cardiothorac Vasc Anesth 2012;26(4):651-3.

Indexed‎: PubMed 21924639

DOI‎: 10.1053/j.jvca.2011.07.012

https://www.ncbi.nlm.nih.gov/pubmed/21924639 (opens new window)

PERIOPERATIVE CARE (PEDIATRICS)
Management and Optimization of Hemostasis
English
Management and Optimization of Hemostasis
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